Dynamical approaches to modeling developmental gene regulatory networks
نویسندگان
چکیده
منابع مشابه
Dynamical approaches to modeling developmental gene regulatory networks.
The network of interacting regulatory signals within a cell comprises one of the most complex and powerful computational systems in biology. Gene regulatory networks (GRNs) play a key role in transforming the information encoded in a genome into morphological form. To achieve this feat, GRNs must respond to and integrate environmental signals with their internal dynamics in a robust and coordin...
متن کاملBuilding developmental gene regulatory networks.
Animal development is an elaborate process programmed by genomic regulatory instructions. Regulatory genes encode transcription factors and signal molecules, and their expression is under the control of cis-regulatory modules that define the logic of transcriptional responses to the inputs of other regulatory genes. The functional linkages among regulatory genes constitute the gene regulatory n...
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Cellular components interact with each other to form networks that process information and evoke biological responses. A deep understanding of the behavior of these networks requires the development and analysis of mathematical models. In this article, different types of mathematical representations for modeling signaling networks are described, and the advantages and disadvantages of each type...
متن کاملProperties of developmental gene regulatory networks.
The modular components, or subcircuits, of developmental gene regulatory networks (GRNs) execute specific developmental functions, such as the specification of cell identity. We survey examples of such subcircuits and relate their structures to corresponding developmental functions. These relations transcend organisms and genes, as illustrated by the similar structures of the subcircuits contro...
متن کاملAssessing regulatory information in developmental gene regulatory networks.
Gene regulatory networks (GRNs) provide a transformation function between the static genomic sequence and the primary spatial specification processes operating development. The regulatory information encompassed in developmental GRNs thus goes far beyond the control of individual genes. We here address regulatory information at different levels of network organization, from single node to subci...
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ژورنال
عنوان ژورنال: Birth Defects Research Part C: Embryo Today: Reviews
سال: 2009
ISSN: 1542-975X,1542-9768
DOI: 10.1002/bdrc.20150